Exercise training ameliorates myocardial phenotypes in heart failure with preserved ejection fraction by changing modi cation in mice model

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SUMMARY

    N6methyladenosine (m6A) methylation is the most common internal mRNA alternation, which affects the metabolism of RNA throughout its life cycle (Wang et_al, 2014a; Wang et_al, 2014b; Alarcón et_al, 2015). The latest evidence shows that m6A modification not only participates in normal biological processes, but also serves vital functions in the occurrence and progression of different heart diseases (Dorn et_al, 2019; Mathiyalagan et_al, 2019; Mo et_al, 2019; Berulava et_al, 2020; Gao et_al, 2020; Krüger et_al, 2020; Lin et_al, 2020). The modification of m6A is related to different types of cardiovascular diseases, including cardiac . . .

     

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