Immunosuppression by hydroxychloroquine: mechanistic proof in in vitro experiments but limited systemic activity in a randomized placebo-controlled clinical pharmacology study

HIGHLIGHTS

• who: Aliede E. in u2018t Veld from the Centre for Human Drug Research, Leiden, The Netherlands have published the paper: Immunosuppression by hydroxychloroquine: mechanistic proof in in vitro experiments but limited systemic activity in a randomized placebo-controlled clinical pharmacology study, in the Journal: (JOURNAL)
• what: The authors aimed to assess and quantify the immunomodulatory effects of HCQ on primary human immune cells, both in_vitro and ex vivo in a randomized clinical trial.
• how: The authors conducted a single-blind randomized placebo-controlled multiple dose study in forty healthy male volunteers comprising twenty . . .
  

   

  

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