Ox2r-selective orexin agonism is sufficient to ameliorate cataplexy and sleep/wake fragmentation without inducing drug-seeking behavior in mouse model of narcolepsy

HIGHLIGHTS

• who: Hikari Yamamoto and collaborators from the International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Ibaraki, University of Tsukuba, Tsukuba, Ibaraki, Japan have published the research work: OX2R-selective orexin agonism is sufficient to ameliorate cataplexy and sleep/wake fragmentation without inducing drug-seeking behavior in mouse model of narcolepsy, in the Journal: PLOS ONE of 22/07/2022
• what: The authors examined whether the selective activation of OX2R is sufficient to rescue the phenotype of cataplexy and sleep/wake fragmentation in orexin knockout mice. Sleep and wakefulness are controlled by . . .
  

   

  

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