Regulator of calcineurin 1 deletion attenuates mitochondrial dysfunction and apoptosis in acute kidney injury through jnk/mff signaling pathway

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  • who: Jing-Jie Xiao from the Animals Animal maintenance and all experiments were performed in accordance with the Chinese Ethics Community Guidelines and approved by the Center for Animal Experiment, Wuhan UniversityMice were maintained in an airconditioned room (, u00b1 , u00b0C) under a , h/, h light/dark cycle and allowed water and standard chow. TECs-specific cadherin, (Cdh16)-Cre transgenic mice were purchased from Shanghai Model Organisms Center, Inc (Shanghai, China). RCAN1flox/flox (RCAN1f/f) mice were generated by CRISPR/Cas9-stimulated homologous recombination. To generate mice with , deletion specifically in TECs, RCAN1f/f mice were crossed with . . .

     

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