HIGHLIGHTS
- who: Rae Hunter from the Emory University GA, USA have published the research: B-cell acute lymphoblastic leukemia promotes an immune suppressive microenvironment that can be overcome by IL-12, in the Journal: Scientific Reports Scientific Reports
- what: To determine the impact of MRD on the cellular immune microenvironment, the authors focused analyses of singlecell RNA-sequencing (scRNA-seq) on non-malignant immune cells derived from pediatric patients with B-ALL. With this model, the authors previously demonstrated that IL-12 promotes T-cell dependent immune clearance of leukemia and prolongs survival.
SUMMARY . . .
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