Single cell sequencing identifies clonally expanded synovial cd4+ tph cells expressing gpr56 in rheumatoid arthritis

HIGHLIGHTS

• who: Alexandra Argyriou from the Center for Molecular Karolinska University, Cambridge, MA, USA have published the Article: Single cell sequencing identifies clonally expanded synovial CD4+ TPH cells expressing GPR56 in rheumatoid arthritis, in the Journal: Rheumatology, Academic Specialist Center, Stockholm Health
• what: The authors demonstrate that clonal expansions are prominent amongst CXCL13high TPH, Treg, effector and cytotoxic CD4+ T_cells in RA SF. The authors show that GPR56 clearly delineates the CXCL13high TPH subset and associates with the expression of tissue-resident memory receptors CXCR6 and CD69 and the inhibitory receptor LAG-3. The authors show . . .
  

   

  

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