HIGHLIGHTS
- who: Mengxue Yu from the Department of Physiology, School of Basic Medical Sciences, Wuhan University, Wuhan, China have published the research: Notch-activated mesenchymal stromal/stem cells enhance the protective effect against acetaminophen-induced acute liver injury by activating AMPK/SIRT1 pathway, in the Journal: (JOURNAL)
- what: The authors investigated the therapeutic potential of human umbilical cord-derived MSCs in APAP-induced acute liver injury and identified a previously unrecognized regulatory mechanism of Notch signaling in MSCs-mediated immunomodulation. This study shows that MSCs-specific Notch signaling regulates macrophage XBP1s/NLRP3 activation for orchestrating inflammatory . . .
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