HIGHLIGHTS
SUMMARY
For instance, numerous studies have demonstrated that T_cell help by CD4+ T_cells is required for anti-tumor efficacy of cytotoxic T_cells. In experimental sarcoma and glioma models, ICI efficacy depends not only on CD8+, but also on CD4+ T_cells, and it has been shown that this also requires activity of antigen-specific CD4+ T_cells in tumors with expression of MHC class II-restricted neoantigens. In terms of enhancing efficacy, overexpression of the micro RNA miR-17-92, a miRNA that has been reported to enhance T_cell survival and interferon production and to be downregulated . . .
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