HIGHLIGHTS
- who: Significance Statement and collaborators from the Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, University of have published the Article: Coordinated Regulation of CB1 Cannabinoid Receptors and Anandamide Metabolism Stabilizes Network Activity during Homeostatic Downscaling, in the Journal: (JOURNAL)
- what: The authors show that BCC-induced chronic hyperexcitation triggers homeostatic downscaling and a coordinated adaptation to enhance tonic eCB signaling. The authors show that BCC-induced downregulation of surface AMPA-type glutamate (AMPARs) and upregulation of CB1 occur through independent mechanisms. Consistent with a previous report . . .
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