Microbe capture by splenic macrophages triggers sepsis via t cell-death-dependent neutrophil lifespan shortening

HIGHLIGHTS

• who: Marianna Ioannou from the (UNIVERSITY) have published the research work: Microbe capture by splenic macrophages triggers sepsis via T cell-death-dependent neutrophil lifespan shortening, in the Journal: (JOURNAL)
• what: The authors show that by controlling fungi and bacteria captured by splenic macrophages, neutrophil-derived myeloperoxidase attenuates sepsis by suppressing histone release. The authors show that MPO protects against immune dysfunction by limiting a pathogenic programme that links T_cell and neutrophil dysfunction. Instead, the authors report a cell population whose Nature Communications | 13:4658 b TCRu03b1-/- c WT WT TCRu03b1-/- WT Infected Naive Infected . . .
  

   

  

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