Global microrna expression profile in laryngeal carcinoma unveils new prognostic biomarkers and novel insights into field cancerization

HIGHLIGHTS

SUMMARY

    Ten microRNAs showed significantly different expression between sample groups (p and amp;lt; 0.05) and exhibited significant dysregulation in peritumor mucosa, consistent with the pattern of dysregulation in tumor samples-miR-1260b, miR-31-3p, miR-31-5p, miR-93-5p, miR-21-3p, miR-181b-5p, miR-130-3p, miR-145-5p, miR-4687-3p, miR-6786-5p. All ten dysregulated microRNAs were validated with RT- PCR in all 240 samples (4 samples per case, 60 patients), along with two additional microRNAs-miR-210-3p and miR-144-3p. RT‑qPCR validation . . .

     

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