Heterozygous expression of the alzheimer’s disease-protective plcγ2 p522r variant enhances aβ clearance while preserving synapses

HIGHLIGHTS

• who: Shiden Solomon from the Department of Basic and Clinical Neuroscience, Institute London, London, UK University of Oxford, Oxford, UK have published the research: Heterozygous expression of the Alzheimeru2019s disease-protective PLCu03b32 P522R variant enhances Au03b2 clearance while preserving synapses, in the Journal: (JOURNAL)
• what: The authors demonstrate that the heterozygous PLCu03b32P522R protective variant modulates microglia-mediated Au03b2 and synaptosome uptake, which may underpin its protective nature in_vivo. The authors show a potential impact of PLCu03b32P522R on microglia mitochondrial function and ATP production, which may contribute to maintenance of microglia metabolic fitness. The authors report . . .
  

   

  

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