HIGHLIGHTS
- who: Pei Gao and collaborators from the (UNIVERSITY) have published the Article: circEXOC5 promotes acute lung injury through the PTBP1/ Skp2/Runx2 axis to activate autophagy, in the Journal: (JOURNAL)
- what: The authors followed up on a novel circRNA, circEXOC5, that was shown to be significantly up-regulated in macrophages from CLP-induced ALI (Bao et al, 2019), and demonstrated its significance in promoting autophagy, inflammation, and ALI, in both CLP-induced ALI model and LPS-challenged MPVEC model. The authors showed that overexpressing Runx2 could reverse the inhibition of silencing circEXOC5 on inflammation and . . .
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