HIGHLIGHTS
- who: Ludovica Iovino from the Department of Biology, University of Padova, Padua, Italy have published the article: Trafficking of the glutamate transporter is impaired in LRRK2-related Parkinsonu2019s disease, in the Journal: (JOURNAL)
- what: The authors show that EAAT2 trafficking is impaired by the leucine-rich repeat kinase (LRRK2) pathogenic variant G2019S a common cause of late-onset familial Parkinson`s disease (PD). Mechanistically the authors report that pathogenic LRRK2 kinase activity delays the recycling of the transporter to the plasma membrane via Rabs inactivation causing its intracellular re-localization and degradation. The authors report . . .
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