HIGHLIGHTS
- who: AAV and collaborators from the DepartmentRutgers University New Jersey, USA have published the research work: Lama2-related dystrophy by, in the Journal: (JOURNAL)
- what: The authors show that, compared with a muscle-specific promoter driving u03b1LNNd, employment of the ubiquitously expressing CBh promoter accompanied by a posttranslational regulatory element driving a shortened version of u03b1LNNd achieves greater muscle benefit along with prevention of amyelination.
- future: Future studies of dystrophic mice following linker protein expression in the brain will be needed to determine if the increased microvascular expression of linker protein and u03b12 . . .
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