HIGHLIGHTS
- who: Li J et al. from the Center for Pharmacogenomics, Department of Internal Medicine, Washington University School of Medicine, StLouis, MO, United States have published the article: Reciprocal Regulation of Mitofusin 2-Mediated Mitophagy and Mitochondrial Fusion by Different PINK1 Phosphorylation Events, in the Journal: (JOURNAL)
SUMMARY
Conventional wisdom holds that mitochondrial fusion is negatively regulated, and mitophagy is positively affected, by selective proteasomal degradation of mitofusins following their ubiquitination by Parkin (Neutzner and Youle, 2005; Cohen et_al, 2008; Gegg et_al, 2010; Poole et_al, 2010; Glauser et_al, 2011; Karbowski and Youle, 2011; McLelland . . .
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