Identification and validation of a novel signature based on nk cell marker genes to predict prognosis and immunotherapy response in lung adenocarcinoma by integrated analysis of single-cell and bulk rna-sequencing

HIGHLIGHTS

SUMMARY

NK cells can participate in anti-tumor immunity in the early presence of tumors by directly killing tumor cells and promoting adaptive T-cell immunological responses, thereby limiting tumor cell aggressiveness. NK and T_cells work together to control cancer progression, indicating the importance of NK cells in shaping anti-tumor immunity, which has also been demonstrated by several previous studies. Given the roles of NK cells in immunity, previous studies have investigated the molecular characteristics of NK cells in infectious diseases and cancers, whereas a comprehensive molecular analysis of NK cells in LUAD is . . .

 



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