Pharmacologic inhibition of histone deacetylase 6 prevents the progression of chlorhexidine gluconate-induced peritoneal fibrosis by blockade of m2 macrophage polarization

HIGHLIGHTS

• who: Yingfeng Shi from the Sichuan University, China have published the paper: Pharmacologic Inhibition of Histone Deacetylase 6 Prevents the Progression of Chlorhexidine Gluconate-Induced Peritoneal Fibrosis by Blockade of M2 Macrophage Polarization, in the Journal: (JOURNAL)
• what: The authors demonstrated that the activation of the PI3K/AKT pathway involved the effect of HDAC6 on M2 polarization. The study showed that TA suppressed the expression of STAT6 in CG-induced peritoneal fibrosis and injured Raw264.7 cells.
• how: Collectively these results showed that inhibition of HDAC6 by TA could block the EMT process . . .
  

   

  

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