HIGHLIGHTS
- who: Hassan Sarker from the University Hospital Magdeburg, Germany have published the paper: Glucocorticoids Bind to SARS-CoV-2 S1 at Multiple Sites Causing Cooperative Inhibition of SARS-CoV-2 S1 Interaction With ACE2, in the Journal: (JOURNAL)
- what: The authors report that cortisol and dexamethasone (endogenous and synthetic glucocorticoids, respectively) can separately and cooperatively interact with SARS-CoV-2 S1 protein and effectively decrease the affinity of S1 for ACE2. The analysis showed that the second ranking high affinity binding pockets were located on the NTD . Based on the HCY /DEX specific pocket search . . .
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