Complete biosynthetic pathway to the antidiabetic drug acarbose

HIGHLIGHTS

• who: Takeshi Tsunoda from the State University have published the Article: Complete biosynthetic pathway to the antidiabetic drug acarbose, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: The authors elucidate step-by-step the biosynthetic pathway to acarbose starting from V7P and establish a complete map of the acarbose pathway, which is different from the proposed pathways described above. The study showed that AcbU can also convert valienol (V) to V1P , albeit with a lower yield (Fig 2c).
• how: The results showed that none of the reaction mixtures gave any products (Supplementary Fig . . .
  

   

  

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