Biochemical characterization of the first step in sulfonolipid biosynthesis in alistipes finegoldii

HIGHLIGHTS

  • who: Christopher D. Radka from the (UNIVERSITY) have published the paper: Biochemical characterization of the first step in sulfonolipid biosynthesis in Alistipes finegoldii, in the Journal: (JOURNAL) of May/10,/2022
  • what: The authors show SulA catalyzes the condensation of acyl-ACP and cysteate (3-sulfo-alanine) to form 3-ketocapnine. The authors show SulA has a bound pyridoxal_phosphate (PLP) cofactor that undergoes a spectral redshift in the presence of cysteate, consistent with the transition of the lysine-aldimine complex to a substrate-aldimine complex. The aim of this study is to biochemically and structurally . . .

     

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