Targeting signaling pathways in prostate cancer: mechanisms and clinical trials

HIGHLIGHTS

• who: Yundong He from the (UNIVERSITY) have published the article: Targeting signaling pathways in prostate cancer: mechanisms and clinical trials, in the Journal: (JOURNAL) of 12/03/2022
• what: Overexpression of EZH2, a histone methyltransferase, is a major reason for the increased genomic distribution of H3K27me3 in metastatic PCa.409 EZH2 plays an important role in promoting lineage plasticity and differentiation changes, which are highly associated with NEPC .
• future: More prospective clinical trials are urgently required for the optimization of treatment sequences and drug combinations that can delay resistance or decrease drug toxicities . . .
  

   

  

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