Metformin alleviates lps-induced acute lung injury by regulating the sirt1/nf- κ b/nlrp3 pathway and inhibiting endothelial cell pyroptosis

HIGHLIGHTS

• who: ARDS and collaborators from the Department of Anesthesiology and Surgical Intensive Care Unit, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China have published the paper: Metformin Alleviates LPS-Induced Acute Lung Injury by Regulating the SIRT1/NF- u03ba B/NLRP3 Pathway and Inhibiting Endothelial Cell Pyroptosis, in the Journal: (JOURNAL)
• what: This study investigated the effect of metformin in NLRP3 inflammasome activation-mediated pyroptosis exposed to lipopolysaccharide (LPS) and in LPS-treated lung ECs. In the experiment , the authors examined whether the inhibition of NLRP3 inflammasome mediated by metformin was . . .
  

   

  

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