HIGHLIGHTS
SUMMARY
More specifically, urinary HLA-DR+ cells and CD8+ T_cells analyzed by flow cytometry (FC) have been suggested as promising biomarkers to detect rejection. The group recently developed a biomarker combination involving urinary T_cells and TEC detected by FC to identify patients with kidney transplant rejection. To find the putatively best biomarker among T_cell subsets, the authors investigated CD4+, CD8+, effector memory, central memory, effector memory T_cells re-expressing CD45RA (termed TEMRA), and HLA-DR+ T_cells. Professional diagnoses by board certified nephropathologists from renal biopsies served to uniquely group graft deterioration into borderline rejection (BR . . .
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