A reduction of syndecan-4 in macrophages promotes atherosclerosis by aggravating the proinflammatory capacity of macrophages

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• who: Jiaxin Hu from the The study protocol with animals was approved by the Institutional Ethics Committee of Nanjing Drum Tower Hospital (Approval No2019-190-01) and performed by following the ARRIVE guidelines and recommendations developed by the National Centre for the Replacement, Refinement, and Reduction of Animals in Research (NC Rs). ApoE-/- mice were purchased from the Model Animal Research Centre of Nanjing University (, weeks old). u00adSDC4-/- mice with a C BL/, background were purchased from Jackson Laboratory. u00ad ApoE-/-, mice and S u00ad, mice were crossbred to obtain u00adSDC4-/-ApoE-/- mice. We provided standard feed . . .
  

   

  

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