HIGHLIGHTS
- who: Zheng-hao Zhang et al. from the Department of Cardiology, Xiamen Key Laboratory of Cardiac Electrophysiology, Xiamen Institute of Cardiovascular Diseases, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China have published the research: Inhibition of GSDMD Activates Poly(ADP-ribosyl)ation and Promotes Myocardial Ischemia-Reperfusion Injury, in the Journal: Oxidative Medicine and Cellular Longevity of 24/06/2022
- what: The authors demonstrated that GSDMD inhibition did indeed reduce myocardial injury in the acute phase of I/R by blocking pyroptosis but significantly activated PARylation through its interaction . . .
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