HIGHLIGHTS
- who: Bo Jiang from the Tower Hospital Nanjing University, Nanjing, China have published the Article: Lysosomal protein transmembrane 5 promotes lung-specific metastasis by regulating BMPR1A lysosomal degradation, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
- what: The authors explore the mechanism that drives the lungspecific metastasis of RCC.
- how: Taken together these data indicated that LAPTM5 enhances the stem_cell-like traits of RCC cells by suppressing the activation of BMP signaling in the lung microenvironment. Immunoblotting results showed that LAPTM5 silencing accelerated the phosphorylation of Smad 1/5/9 in MDA-MB-231 . . .
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