A population pharmacokinetic modelling approach to unravel the complex pharmacokinetics of vincristine in children

HIGHLIGHTS

  • who: A. Laura Nijstad from the Department of Clinical Pharmacy, Medical the Netherlands have published the article: A Population Pharmacokinetic Modelling Approach to Unravel the Complex Pharmacokinetics of Vincristine in Children, in the Journal: (JOURNAL)
  • what: The authors show that younger children have a higher u03b2-tubulin binding capacity for vincristine. To decrease the IOV on Bmax, the authors aimed to look into the effect of thrombocyte levels on the u03b2-tubulin binding capacity.
  • how: In a recently published in-depth literature review based on these findings and the results of other PK . . .

     

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