Prolonged insulin-induced hypoglycaemia reduces ß-cell activity rather than number in pancreatic islets in non-diabetic rats

HIGHLIGHTS

  • who: Vivi F. H. Jensen from the University of have published the paper: Prolonged insulin-induced hypoglycaemia reduces u00df-cell activity rather than number in pancreatic islets in non-diabetic rats, in the Journal: Scientific Reports Scientific Reports
  • what: Using this model, the authors showed that eight weeks of continuous hypoglycaemia was accompanied by microscopically recognizable atrophy of the pancreatic islets of Langerhans, which was reversible within four weeks after ending insulin-infusion17. The aim of this study was to investigate this atrophy further and expand the understanding of the regulation of pancreatic u03b2-cell . . .

     

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