HIGHLIGHTS
SUMMARY
A peptide "S592" (sequence SLEEEWAQIECEVWGRGCPSY13) has been shown to bind competitively to insulin`s site 2 (located on receptor domain FnIII-1 or, equivalently, FnIII-1′)14. The authors show, using single-particle cryo-electron microscopy ("cryoEM"), that IM459 cross-links hIR domain L1 to hIR domain FnIII-1′ and, in so doing, releases constraints on the membraneproximal hIR domain pairs -[FnIII-3] and_[FnIII-2′]-[FnIII-3′]. The map was then interpretable as comprising (i) the four-domain 2 module of the receptor, (ii) an L1-CR module, adjacent to domain L2 and . . .
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