Tumor-specific intracellular delivery: peptide-guided transport of a catalytic toxin

HIGHLIGHTS

• who: Curtis A. Allred from the Laboratory have published the paper: Tumor-specific intracellular delivery: peptide-guided transport of a catalytic toxin, in the Journal: (JOURNAL) of 20/Dec/2022
• what: The authors demonstrate that the optimized MGS4 can deliver the cytotoxic protein saporin specifically to cancer cells in vitro and in vivo resulting in an effective anticancer agent. The authors demonstrate that a monomeric peptide has low nanomolar affinity for its target cells comparable to antibodies while being 1/100th the size. The authors demonstrate that MGS4_V8-saporin has anti-tumor efficacy in a . . .
  

   

  

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