HIGHLIGHTS
SUMMARY
And Background Rheumatoid arthritis (RA) is a multi-etiologic, autoimmune, and chronic inflammatory disorder associated with pain, swelling, morning stiffness, and symmetrical involvement of multiple peripheral joints as destruction of joints is rarely apparent in the early stage. The role of biologics in managing RA is highly dependent on the patient profile and the response of the disease to previous therapy. In commencing phase, prior studies conclude that B and T_cells are triggered primarily by the release of cytokines that play a vital role in RA development. Based on previous studies, cytokines have come . . .
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