Design, synthesis, in silico and biological evaluations of novel polysubstituted pyrroles as selective acetylcholinesterase inhibitors against alzheimer’s disease

HIGHLIGHTS

• who: Hormoz Pourtaher from the DepartmentGulf University of Medical Sciences, Shiraz, Iran have published the paper: Design, synthesis, in silico and biological evaluations of novel polysubstituted pyrroles as selective acetylcholinesterase inhibitors against Alzheimeru2019s disease, in the Journal: Scientific Reports Scientific Reports
• what: A novel series of polysubstituted pyrroles derivatives 4a-4ak were synthesized via simple multicomponent chemical reactions, furnishing excellent yields and producing diverse libraries of polysubstituted pyrroles.
• how: It should be mentioned that some other solvents such as u00adH2O u00adCH3CN u00adCHCl3 THF and DMF were tested and the results showed that EtOH . . .
  

   

  

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