Investigation of native and aggregated therapeutic proteins in human plasma with asymmetrical flow field-flow fractionation and mass spectrometry

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  • who: Ingrid Ramm from the Department of Food Technology, Engineering and Nutrition, Lund University, , Lund, Sweden have published the paper: Investigation of native and aggregated therapeutic proteins in human plasma with asymmetrical flow field-flow fractionation and mass spectrometry, in the Journal: (JOURNAL)
  • what: The aim of this study was to develop a novel in_vitro methodology to provide insight into the behaviour of therapeutic proteins in_vivo. The aim of this work is to demonstrate that after incubation in plasma, serum albumin binding can be investigated and quantified, changes in monoclonal antibody size (oligomerisation and/or . . .

     

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