Phosphosite scanning reveals a complex phosphorylation code underlying cdk-dependent activation of hcm1

HIGHLIGHTS

  • who: Michelle M. Conti from the (UNIVERSITY) have published the Article: Phosphosite Scanning reveals a complex phosphorylation code underlying CDK-dependent activation of Hcm1, in the Journal: (JOURNAL) of 11/01/2023
  • what: The authors show that Phosphosite Scanning identifies multiple combinations of phosphosites that can regulate protein function and reveals specific phosphorylations that are required for phosphorylation at additional sites within a domain. The authors show here that phosphorylation- Nature Communications | 14:310 mediated degradation is important to sensitize Hcm1 to changes in TAD phosphorylation, since phosphomimetic mutations in the TAD do not provide . . .

     

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