HIGHLIGHTS
- who: Matthieu Lu00e9pine from the Cyceron, Bd Becquerel, BP, u201114074, Caen, France have published the research: Parvalbumin interneuron-derived tissue-type plasminogen activator shapes perineuronal net structure, in the Journal: (JOURNAL)
- what: The authors demonstrate that tPA released from FS-PV in the central nervous system reduces PNN density through CSPG degradation. Using conditional mice presenting a depletion of tPA restricted to PV cells, as well as primary culture of interneurons, the authors show that tPA originating from PV cells controls PNN turnover through plasmin. This study provides the first demonstration that tPA expressed by . . .
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