Impaired il-23 dependent induction of ifn- γ underlies mycobacterial disease in patients with inherited tyk2 deficiency

HIGHLIGHTS

• who: Freiburg and colleagues from the Rockefeller University for Sick Children, Paris, France have published the article: Impaired IL-23 dependent induction of IFN- u03b3 underlies mycobacterial disease in patients with inherited TYK2 deficiency, in the Journal: Rheumatology, of 27/02/2023
• what: The authors report three new forms of deficiency in six patients from five families homozygous for rare alleles (R864C G996R G634E or G1010D) or compound heterozygous for P1104A and a rare allele (A928V). The experiment shown is representative of at least two independent experiments performed.
• how: The authors studied the . . .
  

   

  

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