A novel morphological parameter predicting fibroticevolution in myeloproliferative neoplasms: new evidence and molecular insights

HIGHLIGHTS

  • who: Vincenzo Fiorentino et al. from the Unicamillus, International Medical University in Rome, Rome, Italy have published the paper: A Novel Morphological Parameter Predicting FibroticEvolution in Myeloproliferative Neoplasms: New Evidence and Molecular Insights, in the Journal: (JOURNAL)
  • what: The authors focused the role of the megakaryocytic lineage in the various stages of MPNs with updated examples of MPNs in vitro and in vivo models and therapeutic implications. The current model proposes that megakaryocytes lacking G6b-B develop normally, while proplatelet release is hindered, but the underlying molecular mechanism remains unclear.
  • future: This parameter . . .

     

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