HIGHLIGHTS
SUMMARY
AQPs are expressed in many different cell types of the skin and contribute to several of the skin`s key functions including hydration, formation of water-permeability barrier, and immune_responses. The immune barrier consists of skin-resident immune cells populating the epidermis, such as keratinocytes, epidermal Langerhans cells, and the dermis, such as dendritic cells and resident T_cells. LCs and dDCs uptake antigen and subsequently migrate to regional draining lymph nodes, where they activate naive T_cells by initiating the immune_response. AQP9 was therefore suggested to be required for the development of sensitization during cutaneous . . .
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