HIGHLIGHTS
SUMMARY
Subgroups manifested similar lipid metabolic patterns, immunosuppressive functions and TFs module at the end of the differentiation trajectory in CD8+ T_cells, myeloid cells and Fibroblasts. The exhausted CD8+ T_cells (Tex) were characterized by progressive and hierarchical loss of cytokine production, high co-expression of inhibitory receptors (programmed cell death 1 (PD-1), lymphocyte activation gene 3 protein (LAG3), T_cell immunoreceptor with immunoglobulin and ITIM domain (TIGIT), etc.), altered expression of key transcription factors and metabolic derangement. The authors extracted the transcripts per million (TPM) normalization datasets of selected cell types including CD8+ T_cells, myeloid . . .
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