Inhibition of cyp2c8 by acyl glucuronides of gemfibrozil and clopidogrel: pharmacological significance, progress and challenges

HIGHLIGHTS

• who: Manish B. Shah from the (UNIVERSITY) have published the research work: Inhibition of CYP2C8 by Acyl Glucuronides of Gemfibrozil and Clopidogrel: Pharmacological Significance, Progress and Challenges, in the Journal: Biomolecules 2022, x of 12/07/2022
• future: Such analysis can help with future drug discovery projects by elucidating the mechanism of CYP2C8 inhibition that leads to DDI. Studies are needed to validate the use of gemfibrozil as an enhancer of pharmacokinetic activity.

SUMMARY

The active_site of CYP2C8 is large and comparable in size to the active_site of CYP3A4 and 2C9 . . .

 



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