HIGHLIGHTS
- who: Ashley N. Barlev and colleagues from the Zucker School Leiden University have published the article: Fcu03b3RIIB regulates autoantibody responses by limiting marginal zone B cell activation, in the Journal: (JOURNAL)
- what: The authors show that loss of Fcu03b3RIIB in B cells led to aberrant marginal zone (MZ) activation and subsequent extrafollicular autoreactive PC responses.
- how: Similar results were obtained using conventional gating (data not shown).
SUMMARY
FcγRIIB is an inhibitory receptor expressed on many cell types, including B cells. The effect of FcγRIIB on autoantibody production . . .
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