Functional crosstalk between pcsk9 internalization and pro-inflammatory activation in human macrophages: role of reactive oxygen species release

HIGHLIGHTS

• who: Rafael I. Jau00e9n and colleagues from the Instituto de Investigaciones Biomu00e9dicas Alberto Sols, CSIC-UAM, Madrid, Spain Departamento de Farmacologu00eda, Farmacognosia y Botu00e1nica, Facultad de Farmacia have published the research work: Functional Crosstalk between PCSK9 Internalization and Pro-Inflammatory Activation in Human Macrophages: Role of Reactive Oxygen Species Release, in the Journal: (JOURNAL)
• what: This work shows an additional mechanism of action of PCSK9 in Mu03d5 involving TLR4 activation, implicating the regulation of a plethora of responses, including lipid metabolism, inflammation, and apoptosis.

SUMMARY

Proprotein convertase subtilisin/kexin type 9 . . .

 



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