HIGHLIGHTS
- who: OPINION from the (UNIVERSITY) have published the article: Revision of ICH S8 Needed?, in the Journal: (JOURNAL)
- future: If penetration through the skin is expected to be low further study might not be needed as immunotoxicity is only to be expected after systemic exposure. Frontiers in Toxicology | www.frontiersin.org April 2022 | Volume 4 | Article 866737 Future Directions the need for a full carcinogenicity study.
SUMMARY
In a comparative study on mouse spleen with well-known immunotoxicants (Tributyltinoxide, Cyclosporin A, and Benz Pyrene), paracetamol (acetaminophen) was clearly identified as a . . .
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