HIGHLIGHTS
- who: Riccardo Rigo and collaborators from the Institut Sud University , Biotechnology and Cell Signaling, Illkirch, France have published the research work: TET2 regulates immune tolerance in chronically activated mast cells, in the Journal: (JOURNAL)
- what: The authors show that in primary mast cells Tet2 expression is induced in response to chronic and acute activation signals. While a role for TET2 in the inflammation response in myeloid cells has now been accepted in the field, here the authors report a tolerant phenotype associated to the immune function of TET2-deficient cells. The study was approved by . . .
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