Cefiderocol protects against cytokine- and endotoxin-induced disruption of vascular endothelial cell integrity in an in vitro experimental model

HIGHLIGHTS

• who: Dagmar Hildebrand et al. from the Medical Microbiology and Hygiene, Department of Infectious Diseases, Heidelberg University, Department of Infectious Diseases and Microbiology, University of Lu00fcbeck, Lu00fcbeck, Germany have published the research: Cefiderocol Protects against Cytokine- and Endotoxin-Induced Disruption of Vascular Endothelial Cell Integrity in an In Vitro Experimental Model, in the Journal: Antibiotics 2022, 11, 581. of /2022/
• what: Our in_vitro investigation implied that cefiderocol may have immunodomulatory properties, which warrants further in_vivo validation and investigation to elucidate the underlying mechanisms.
• how: Similar observations were made for LPS (p=0.05 . . .
  

   

  

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