HIGHLIGHTS
- who: Aiping Zheng from the University of Macau, China have published the paper: The role of cancer-associated mesothelial cells in the progression and therapy of ovarian cancer, in the Journal: (JOURNAL)
SUMMARY
ITLN1 increased recombinant glucose transporter-4 (GLUT4) production in adipocytes, which contributed to increased glucose uptake by adiposes and decreased glucose uptake by tumor cells, thereby the proliferation of OC cells was inhibited. Pericellular hyaluronic acid (HA) secreted by CAMs can bind to CD44v3-Vav2 complex on OC cells to activate RhoGTPase (Rac1) pathway signaling, in turn, promoted the activation . . .
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