De novo emergence, existence, and demise of a protein-coding gene in murids

HIGHLIGHTS

SUMMARY

    Protein-coding genes usually evolve through some mechanism involving an existing protein-coding_sequence as evidenced by clusters of orthologous groups and conserved protein domains. D6Ertd527e encodes a serine-rich protein and its coding_sequence (CDS) largely evolved from an expanding and mutating (CAG)n repeat. While the (CAG)n repeat expansion and the coding_sequence considerably vary among Muroidea genomes, the unique 3′ UTR sequence of D6Ertd527e is conserved across placental mammals (Additional file 1: Fig S1b). Protein‑coding potential of D6Ertd527e D6Ertd527e transcripts originating from the MTD promoter carry predicted coding_sequences of variable lengths and . . .

     

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