Nanoscale regulation of ca2+ dependent phase transitions and real-time dynamics of sap97/hdlg

HIGHLIGHTS

• who: Premchand Rajeev from the Indian Institute have published the research: Nanoscale regulation of Ca2+ dependent phase transitions and real-time dynamics of SAP97/hDLG, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: Using single-molecule localization microscopy in combination with Ca2+ perturbation and analysis paradigms to evaluate the free_energy change in protein aggregation, the authors show that the nanoscale condensation of SAP97/hDLG followed a firstorder phase transition with spontaneous nucleation and growth. The model proposes a higher nucleation barrier and critical cluster radius in these conditions, implying that the cells are in a . . .
  

   

  

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