HIGHLIGHTS
SUMMARY
Ovarian cancer (OC) is a heterogeneous disease with a variety of subtypes. In a study on lung adenocarcinoma patients, PDPN + CAFs showed higher expression of TGFB1 and were associated with CD204 + TAM infiltration in stage I lung squamous cell cancer (SqCC), suggesting that PDPN + CAFs were associated with an immunosuppressive tumour microenvironment. Tumour-infiltrating lymphocytes (TILs), as the main components of the immune microenvironment, include B cells, CD4 + T_cells and CD8 + T_cells. LRRC15 is indeed related to the primary resistance of ovarian cancer, and treatments targeting LRRC15 may reverse ovarian cancer primary resistance. To . . .
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